After. It is also used for women who. 5 milligrams (MG) dosages. 5. Treatment should be discontinued at tumor relapse. Letrozole is approved to be used alone or with other drugs to treat: Breast cancer in postmenopausal women who have any of the following types of breast cancer--. Lez-T Letrozole 2. Brand Name Price Savings;. A single-blind, crossover trial of 72 women whose HR+ breast cancer progressed on tamoxifen were randomized to either letrozole or anastrozole for four weeks and then crossed over to the other AI for another 4 weeks found significantly less reported joint pain in the letrozole arm than the anastrozole arm (3% vs 11%; p=0. Clinical particulars. When you stop taking letrozole, most persistent side effects should improve within a week or 10 days, and as long as you have taken it for at least 5 years, then letrozole should continue to reduce the risk of breast cancer coming back for many years after you stop taking it. Official answer. Letrozole 2. Still, there was a similar incidence between the letrozole and the control groups,. It may also be used off-label for fertility issues. sudden, severe weakness or numbness in the arm or leg. The enthusiasm over letrozole’s potential grew even more following the completion of a successful in-house phase 1 study in healthy male volunteers, which used a letrozole solution instead of tablets in order to speed up the development process . to treat breast cancer in men and younger women. Letrozole is a third-generation aromatase inhibitor that is used mainly for the treatment of postmenopausal breast cancer. There is no evidence that the exposure of the oocytes to letrozole increases congenital defects at birth. Thus, letrozole was expected to have a potential of improving luteal function and outcome in patients with advanced maternal age. 5 Tablet is used in the treatment of Breast cancer,Infertility due to anovulation. Letrozole is used to treat breast cancer in postmenopausal women. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. Letrozole is an aromatase inhibitor indicated for: Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Letrozole 2. Call your doctor for medical advice about side effects. As a result, it can lower the rate of testosterone-to-estrogen conversion and estrone to androstenedione, decreasing the negative feedback on the hypothalamus through the inhibition of aromatization [26]. Treatment should be discontinued at tumor relapse. vaginal bleeding. Instead, the Body Fat, using a Protein called Aromatase, produce it. These. pain in the chest, groin, or legs, especially the calves. 3 Use in Extended Adjuvant Treatment of Early Breast Cancer. 100% authentic medicine with nationwide delivery. It sounds like your OB isn’t monitoring you. increased blood pressure. The Benefits of Using Letrozole for Pregnancy. What Femar is and how it works. A comparative study of letrozole and tamoxifen showed that when used as a first-line treatment, letrozole slowed the progression of breast. While the rates of clinical or biochemical pregnancy and implantation were similar between the groups, the miscarriage rate was significantly lower in the letrozole group (9. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. After surgery, women who have hormone receptor positive breast cancer will have hormone therapy as part of their treatment. View uses, side effects, price in Pakistan and get expert advice. So, your ovaries produce more. This article was originally published December 14, 2022 and most recently updated. Letrozole (LE) is a drug commonly used to induce ovulation. We retrospectively reviewed the medical files of women. 008) at 24. 3%) had hypoestrogenic. DesignRetrospective observational study. It works by decreasing the amount of estrogen hormone your body makes, which slows or stops breast cancer cells from spreading or growing. The women were then separated into two groups: Group 1- received Letrozole in combination with gonadotropin fertility drugs. Guideline-Supported Use. 33) and natural cycle (OR 1. Written by ASHP. 5% of IUI cycles actually result in twins or triplets being born. 0) Other: 5 (3. 5 to 7. 1% taking tamoxifen; this was highly significant . The high suppression of estradiol reached in this study is similar to the results published in the literature [ 9 , 19 ]. Letrozole tablets may cause fetal harm when administered to a pregnant woman and the clinicl benefit to premenopausal women with breast cancer has not been demonstrated. It may also be used off-label for fertility issues. Letrozole can stop or slow the growth of these cancers. 1, 5, 9, 10 It is a third generation aromatase inhibitor like exemestane and anastrozole, meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Belly pain. “Any time” includes follow-up period after completion or discontinuation of study treatment. In this study, we characterized adult heights and long-term follow-up in AI-treated boys with ISS. 1. letrozole. However, the degree of. Letrozole is also used to help prevent the cancer from returning. Super Quick Home Delivery with COD No Minimum Order Value Pan India Delivery. In this video i am telling about lezra tablet. Typical dosage. It is used for estrogen receptor-positive breast cancers [1, 2]. The procedure itself involves transferring semen that has been washed and concentrated directly into the uterus via a. There are a number of other brands of letrozole, all of which contain. The bottom line. Letrozole as an aromatase inhibitor has been widely used in the treatment of female infertility [20–22]. Advise pregnant women of the. It’s prescribed for adult females*. For vaginal complaints such as dyspareunia, dryness and sexual dysfunction, topical estrogen may be considered. 2. 1) Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy. Bundred N, Campbell I, Coleman R, et al: Zoledronic acid in the prevention of cancer treatment-induced bone loss in postmenopausal women receiving letrozole as adjuvant therapy for early breast cancer (ZO-FAST study). m. massage. 5 Tablet (strip of 10 tablets) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg. In this video i am telling about lezra tablet. Letrozole is approved for use in the following clinical indications Adjuvant Treatment of Early Breast Cancer. 5’ on other side. Estrogen use with letrozole: use other options for conditions in which estrogen is indicated. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. The growth of some breast cancers in postmenopausal women is. According to the latest guidelines, letrozole should be considered as the first-line pharmacological treatment for women with WHO Group II anovulation or PCOS. Estrogen use with letrozole: use other options for conditions in which estrogen is indicated. 1. Lezra tablet contains Letrozole | belongs to Non-steroidal aromatase inhibitor. 2. Eat a bigger breakfast and a smaller dinner. These breast cancers are called hormone sensitive or hormone receptor positive. Timed intercourse is the simplest and least invasive “fertility treatment,” that is paired with Letrozole. Letrozole is not a drug that is used recreationally or abused. Letrozole Post-cycle therapy is a critical phase that aims to restore hormonal balance, enhance natural testosterone production, and mitigate any potential side effects of a cycle. siponimod and letrozole both increase immunosuppressive effects; risk of infection. It only works in women who are post-menopausal and producing estrogen outside the ovaries. Put on gloves to avoid touching the. No experience with letrozole overdose has been reported. Letrozole can induce ovulation in some of these women. Post Views: 3,192. Letrozole के लाभ और उपयोग करने का तरीका - Letrozole Benefits & Uses in Hindi Letrozole इन बिमारियों के इलाज में काम आती है - Use of letrozole in CDGP was associated with a slower progression in BA when compared to those receiving placebo or testosterone. Buch‐Larsen K, Lund‐Jacobsen T, Andersson M, Schwarz P. vision changes. Objective: The object of this study was to evaluate the efficacy of letrozole co-treatment with GnRH-antagonist protocol in ovarian stimulation of poor responder patients undergoing intracytoplasmic sperm injection. Consideration should be given to monitoring BMD. Femara strength. SingleCare discount cards can be used at participating pharmacies, but discounts will vary by pharmacy. If a family member, friend, or caregiver needs to . vision changes. Femara form. FDA approved Letrozole as an anticancer medication to treat t early and advanced hormone receptor-positive breast cancer in postmenopausal women on 25th July 1997. Find out more about blood clots. A more recent analysis of a prospective trial involved the aromatase inhibitor letrozole under a 5-year study period and analyzed data from 120 breast cancer patients of the adjuvant endocrine. A significantly greater number of participants receiving letrozole than those receiving placebo had a T score at the lumbar spine that was less than −2. 1 Adjuvant Treatment of Early Breast Cancer - Letrozole tablets are indicated for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Common Femara side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or. Include more protein and greens in your meals. It is also used to treat early breast cancer in women who have experienced menopause and who have. 21. 5mg of Letrozole/Femara cd 3-7 with in-office monitoring. Always take letrozole exactly as your doctor has told you. Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. 1 Bone Effects. 1) Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy. Letrozole Tablets, USP are indicated for first-line treatment of postmenopausal women with hormone receptor positive or unknown, locally advanced or. Instead, the Body Fat, using a Protein called Aromatase, produce it. It may be done with or without fertility drugs. Letrozole is a powerful endocrine medication that targets and inhibits the aromatase, often known as an aromatase inhibitor (AI). It works by lowering the amount of estrogen the body produces. 5 milligram tablet daily for breast cancer. Letrozole is a nonsteroidal aromatase inhibitor that reversibly binds to aromatase enzyme, and inhibits estrogen synthesis. letrozole. The GnRHa used for pre-HIFU treatment in group C patients can generate significantly more volume reduction of leiomyomas than letrozole used in group B patients (38. 5 mg orally daily. It’s FDA-approved to treat certain types of breast cancer. Letrozole (Femara): How to Use Letrozole for Fertility, its Side Effects, and more February 5, 2022 June 27, 2023. These are not all of the side effects that may occur. It works by keeping a certain hormone (estrogen) from stimulating the growth of breast cancer cells. to treat breast cancer in men and younger women. Letrozole, an aromatase inhibitor, is a commonly used neo-adjuvant drug to treat hormone-sensitive breast cancer. Not able to sleep. If estrogen is used, prescribe the lowest dose to relieve symptoms, monitor patient carefully and consider short term use. The planned duLetrozole tablets USP, 2. Across all patients, IUI cycles have live birth rates per cycle of 5 - 15% and multiples-per-pregnancy of 8 - 30%. Of the 23 boys recruited, 19 (9 on T + Lz, 10 on T + Pl) completed the initial 18-month follow-up. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. Recently, many studies have shown letrozole to be advantageous in IVF cycles, particularly in patients with breast cancer and undergoing treatment to preserve fertility (9-12). Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. Letrozole (Femara) is an oral medication that lowers estrogen levels by blocking the enzyme (protein) aromatase. The most frequently reported adverse reactions were bone pain, hot flushes, back pain, nausea, arthralgia and dyspnea. 044) and a significant decrease in lumbar spine BMD (percentage change in T score, mean −0. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Note: “During treatment” includes 30 days after last dose. Despite this growing use, our understanding of the impact of letrozole on pregnancy outcomes in FET cycles is still in the early stages. If estrogen is used, prescribe the lowest dose to relieve symptoms, monitor patient carefully and consider short term use. The growth of breast tumors is often stimulated by the female sex hormone estrogen. Cytostatic. dizziness or lightheadedness. It is a hormonal (or "endocrine") treatment for breast cancer. Lesbian-specific success rates for each treatment are explained along with risks. Consideration should be given to monitoring BMD. IUI, or intrauterine insemination, is a relatively simple fertility treatment. 1. Check with your doctor immediately if any of the following side effects occur: chills, fever, or flu-like symptoms. Concerns. Learn about side effects, off-label use for infertility, and more. 044) and a significant decrease in lumbar spine BMD (percentage change in T score, mean −0. Filter by condition. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Peripheral oedema, chest pain. What is this medication? LETROZOLE (LET roe zole) treats some types of breast cancer. , during the weekend, or on a holiday, call 212-639-2000. headache*. 2. The growth of breast tumors is often stimulated by the female sex hormone estrogen. 24, 95% CI 1. It is a hormonal (or "endocrine") treatment for breast cancer. See moreWhat is this medication? LETROZOLE (LET roe zole) treats some types of breast cancer. It has been prescribed by fertility doctors since the early 2000s. Letrozole may be used with intracytoplasmic sperm injection cycles, particularly as a successful means of delivering in vitro fertilization care at an affordable price . However, one side effect that can be particularly uncomfortable is gas and bloating. and R$50 - R$300 in Brazil. uses. 2) First and second-line treatment of. View Lez 2. Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. There are limited studies that have evaluated the therapeutic potential of letrozole in male infertility [15–19]. 16. It is usually used when you have been through a natural menopause. IUI costs between $300 and $1,000 per try, and the chances of getting pregnant each cycle are just 15% to 20%, even when there are no fertility issues involved. Call your doctor for medical advice about side effects. Levalbuterol comes as a solution (liquid) to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled), a concentrated solution to be mixed with normal saline and inhaled by mouth using a nebulizer, and as an aerosol to inhale by mouth using an inhaler. We cover the options for lesbian women doing artificial insemination, either at home, or an IUI intrauterine insemination through a doctor, including the choice of whether to use medications like clomid, letrozole, or gonadotropins. Letrozole Orion reduces the amount of estrogen by blocking an. SPSS19. 1, 5, 9, 10 It is a third generation aromatase inhibitor like exemestane and. Letrozole (Femara) is type of hormone therapy called an aromatase. Letrozole is a targeted aromatase inhibitor which has primarily been used in post-menopausal women with breast cancer. Some forms of cancer cells of breast that require estrogen to proliferate can be slowed or stopped by this. , 2008; Kar, 2013). The results of this study showed that letrozole treatment in iOAT patients with T:E 2 ratio ≤ 10 can increase testosterone level, decrease estradiol level and improve T:E 2 ratio (1600%) as well as hormonal balance, which regulate male reproductive functions. Get Flat 27% OFF on first 3 medicine orders. Letrozole is a selective and highly potent aromatase inhibitor that inhibits the enzyme activity of intracellular aromatase. You may also hear it called Femara, which is its best-known brand name. Consideration should be given to monitoring BMD. Letrozole works by lowering your estrogen levels which slows/reverses some cancers from growing. Femara induces ovulation in patients with polycystic ovary syndrome (PCOS), which is a condition where hormone imbalance can. 60 for placebo and letrozole, respectively; P = . Frequently asked questions. Clomid (Clomiphene citrate) has been the most commonly prescribed oral fertility drug for over 50 years. Letrozole 2. 1 Bone Effects. In fact, with Clomid, having more than six cycles is discouraged (a max of three to four is recommended). It prevents the recurrence of cancer. 5) 0 (0. Obtaining information on the quality of the oocytes retrieved after the extended use of letrozole is therefore fundamental. In these studies, 5 mg daily letrozole was given with gonadotrophins, from the first day of ovarian stimulation until the trigger day in antagonist cycles in a trial to improve ART outcome ( Haas et al. What Femar is and what it is used for. 3 DOSAGE FORMS AND STRENGTHS. 5 mg once daily for a planned duration of 5 years; discontinue at relapse. In Menopausal Women, the Ovaries do not produce Estrogen. . These side effects can often be managed with lifestyle changes. 5 mg tablet. Methods Our retrospective cohort included all LTZ-FET (n = 161) and NC-FET (n = 575) cycles that transferred a single euploid autologous blastocyst from 2016 to 2020 at Stanford Fertility Center. Letrozole may be used with intracytoplasmic sperm injection cycles, particularly as a successful means of delivering in vitro fertilization care at an affordable price . Based on our results, it is advisable to evaluate serum lipid levels every 3 months during the initial 6 months of AI treatment, and thereafter after. Letrozole may be given to you for other. 2. It is in the aromatase inhibitors class of drugs. In addition, in a study (AR/BC2) of 347 patients with advanced breast cancer, about half of whom received 2. It can also cause more fatigue (lack of energy). Sequential endocrine therapy with tamoxifen for 2–3 years followed by letrozole for 5. 5mg letrozole for improving fertility. m. 2 Use of Lez-T and Food: The tablet can be taken with or without food. Previous studies suggested a possible association with metabolic and liver adverse effects. Letrozole is a medication used in the treatment of certain breast cancers. The study design of SOLE—4 consecutive years with a 3-month letrozole treatment interruption and a final year of continuous letrozole use (year 5), following completion of 4–6 years of adjuvant anti-oestrogen (tamoxifen or an aromatase inhibitor) therapy, versus 5 years of continuous letrozole—is really a test of preplanned noncompliance rather than. Letrozole was developed after Arimidex but before Aromasin, and it is the strongest and most potent of the three aromatase inhibitors by far. 5mg (USP Specs) Price:…Abstract. Have a regular-ish long cycle (35-40 days) with sporadic late ovulation on day 22 ish. 5 Tablet is used for Breast Cancer etc. Letrozole, when used in the metastatic setting, is associated with a lower overall incidence of thromboembolic events as compared to tamoxifen. Letrozole Teva contains an active substance called letrozole. Consideration should be given to monitoring BMD. Belly pain. The incidence of vertebral deformation in children with idiopathic short stature increased after letrozole was used. m. 5 mg tablet. com. Use of letrozole may cause decreases in bone mineral density (BMD). Use of letrozole may cause decreases in bone mineral density (BMD). If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. Prices vary from pharmacy to pharmacy. Side effects after stopping letrozole. When you take it for 5 days in a row, ovulation usually kicks in and continues for. 2. Consideration should be given to monitoring BMD. 007). Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. Doctors usually recommend women to take around 2. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. I am on year 8 taking Letrozole. 5 mg Film-coated tablets should only be used in women with a clearly established postmenopausal status (see section 4. Modify Therapy/Monitor Closely. 5 mg Tablets While letrozole has a very good safety profile, other medications can be used in people who don’t tolerate it. 2019, 112:371-7. Letrozole, an aromatase inhibitor,. We were trying for two years before seeing a doc, and got ourselves into optimal shape and fitness during that time in pursuit of this baby goal. If you're a patient at MSK and you need to reach a provider after 5 p. Introduction and background. Introduction. sudden loss of coordination. 16. Letrozole is also used to induce ovulation in women who exhibit polycystic ovary syndrome or anovulation. In the crude analysis, live birth rate/embryo transfer was 54. Letrozole (trade name Femara) is an oral aromatase inhibitor (AI) used in the treatment of hormonally responsive breast cancer after surgery. 008) at 24. 5mg 2. It should be used under the supervision of a qualified physician. Letrozole is also emerging as a. An RE could monitor you pre/post ovulation to check your follicles, hormones, etc to see if everything is working correctly. Introduction For Lezra Excel 2. Letrozole is an aromatase inhibitor. , during the weekend, or on a holiday, call 212-639-2000. Arimidex is sometimes taken to lower estrogen levels that are high due to anabolic steroid use. While Letrozole is the preferred medication for PCOS based on. For Patients with Ovulatory Issues or PCOS. Letroz 2. Symptoms of a mild allergic reaction can include: skin rash. Monitoring of cholesterol levels is necessary. ) [1] . Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a. Letrozole (Femara) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. Use of letrozole may cause decreases in bone mineral density (BMD). It is used as the second treatment. constipation. ( 1. Letrozole 2. 5 mg once per day. 29bluethink. Femara may be used to treat postmenopausal women whose cancers are fueled by hormones. 5 MG: PRESCRIPTION REQUIRED: Mandatory: PRODUCT FORM: Tablet: ABOUT: Lezole 2. ( 1. tablet that you swallow. 5 mg, taken cycle days 3-7). pain in the chest, groin, or legs, especially the calves. Letrozole is an aromatase inhibitor used to treat breast cancer in postmenopausal women. View Letroz Tablet (strip of 5. Many cancers are hormone sensitive (estrogen or progesterone receptor positive) and their growth can be affected by lowering estrogen levels in the body. 4%, p = 0. It can also be used in premenopausal women having ovarian suppression. Consideration should be given to monitoring BMD. 0 was used to analyze the data. Letrozole can sometimes also be used: to prevent breast cancer if you are high risk and have been through the menopause. Letrozole inhibits the enzyme in the adrenal. Letrozole comes in 2. If a woman doesn't ovulate on her own, she can start medications at any time after documentation of a negative pregnancy test. Letrozole is a nonsteroidal oral aromatase inhibitor. 5mg. Usage Instructions for Letrozole; Take this drug at the same time of day. increased cholesterol in your blood. Whenever possible, give letrozole to yourself and follow the steps below. Hair loss. , 2014 ), and no studies have investigated the. Oral. 1 Recommended Dose - The recommended dose of letrozole tablets is one 2. Indications and Dosage. Drug Images What is letrozole? If you have a certain type of breast cancer, your doctor may prescribe letrozole oral tablets for you. In patients with advanced disease, treatment with Letrozole Tablet should be continued until tumor progression is evident. Lezra is used to treat postmenopausal breast cancer. Verywell / Cindy Chung. 5 mg tablets in generic forms and under the brand name Femara. If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. Letrozole is a nonsteroidal compound that inhibits estrogen production by blocking the enzyme aromatase. It has been prescribed by fertility doctors since the early 2000s. Follicular development can be induced by the administration of letrozole via suppressing androgen conversion into oestradiol and increasing serum gonadotropin-releasing hormone levels []. The dosage usually lasts for 5 days to a week, if a tablet is taken every day. In cases where Letrozole is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until tumor comes back, whichever is first. Elderly people (65 years of age and above) Patients 65 years of age and over can use Lez-T at the same dosage as other adults. It’s produced mainly by adrenal glands as well as the testicles. The aim of this study was to evaluate letrozole use on patients with normal menstrual cycles. sudden, severe weakness or numbness in the arm or leg. Know Letroz 2. Some side effects are very common (may affect more than 1 user in 10): Hemorrhoids. But this combination can potentially cause rare adverse effects in the body, including kidney toxicity [95]. However, the use of letrozole as an ovulation induction agent is not FDA or EMA. Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. . It works by lowering the amount of estrogen the body produces. 05±4. Geranium: has an overall balancing effect on female hormones. If you have questions about side effects, call your doctor. The LTZ-FET protocol entailed 5 mg. Letrozole is known for its effects in fertility. (BW) of 61. The ideal time to begin is on the third or fourth day of the cycle. This is a decision. Read about the uses, dosage, treatment, side-effects & FAQs. Letrozole is a nonsteroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Take with or without food. Letrozole uses. What side effects can Letrozole cause? Bone pain, joint pain or muscle ache. 5 mg letrozole and half 0. View Letroz Tablet (strip of 5. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. flushing (temporary warmth, redness. fast or pounding heartbeat. 4). We believe, in the light of the accumulating clinical research evidence, that letrozole is safe for use in assisted reproduction. Letrozole inhibits the liver enzyme CYP2A6, and to a lesser extent CYP2C19, in vitro, but no relevant interactions with drugs like cimetidine and warfarin have been observed. Discontinuations for adverse reactions other than progression of tumor occurred in 10/455 (2%) of patients on Femara and in 15/455 (3%) of patients on tamoxifen.